Madson Aragão

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Bioinformatician | Research & Development Analyst | Product Manager

Bits, Bytes & Biomolecules:
Bridging Science and Technology to Build the Future

Combining expertise in Bioinformatics with AI-driven strategies.

About Me

Currently, as a PhD student in Bioinformatics, I'm deepening my expertise in Machine Learning, Genomics, Transcriptomics, Structural Biology and Chemoinformatics. My research applies deep learning algorithms, focusing on generative models to extract biological insights from complex datasets, with the goal of developing an antimicrobial language for generating synthetic compounds inspired by the immune system of diverse organisms. My ultimate goal is to provide actionable insights for the development of new therapeutics against antimicrobial resistance, using scalable in silico methods.

Simultaneously, I'm also a MBA student in Software Engineering & Data Science, where I'm expanding my expertise in key areas such as data analysis for strategic insights, advanced machine learning, data engineering and governance.

I hold a Master’s degree in Genetics and Molecular Biology, during which I developed the AMP-Identifier, a machine learning tool designed to identify antimicrobial sequences in genomic data. This tool has shown promising potential in uncovering bioactive compounds in genomes, fostering progress in drug discovery and bioproduct development. Additionally, I hold a Bachelor’s degree in Biomedical Sciences, with a focus on Bioinformatics and Clinical Pathology. I gained practical experience in hospitals and molecular biology research laboratories and further developed my skills in computational biology working as a bioinformatics intern in research centers.

In the private sector, I worked as Research and Development Analyst, focusing on the end-to-end development of IoT and AI products. My responsibilities included building roadmaps, defining KPIs, developing MVPs and leading user feedback collection to guide product upgrades. By leveraging data-driven decision-making and applying machine learning to health data, I delivered efficient user-centric solutions. Using Agile, Lean and Scrum approaches, I worked on optimizing team performance and ensuring a well-designed project delivery. Additionally, I conducted market research to identify trends, collaborated with stakeholders to align goals and ensured continuous improvement through agile retrospectives.

Combining skills in research, product management and agile methods, I’m ready to deliver innovative solutions to real-world challenges in general products and especially in life sciences and healthcare, enhancing technology and user experience.

Skills

Bioinformatics

  • Genomics & Transcriptomics
  • Structural Genomics
  • Genome Mining and Annotation
  • Molecular & Structural Biology
  • Protein & Membrane Modeling
  • Chemoinformatics & Protein Design
  • Molecular Dynamics Simulations
  • Pipeline Development

AI, Data & Scripting

  • Machine Learning (Supervised, Unsupervised, Generative Networks)
  • Data Analysis & Visualization
  • Data Engineering & Governance
  • Python, Bash & SQL
  • Linux/Unix Systems
  • HPC Workload Management

Product/Project Management

  • Product Lifecycle Management
  • Agile Methodologies (Scrum, Kanban)
  • User-Centered Design (UCD)
  • Roadmap Development
  • Key Performance Indicators (KPIs)
  • Market & User Research
  • Lean Product Development / MVP
  • Design Thinking

Product Lifecycle Management

  • Figma, Miro, Jira, Trello & Azure
  • Git & Version Control
  • Google Workspace & Notion
  • Tableau & PowerBI

Collaboration & Communication

  • Cross-Functional Team Leadership
  • Stakeholder Management
  • Technical & Business Communication
  • Complex Problem-Solving
  • Data Storytelling

Key Soft Skills

  • Active Listening
  • Critical Thinking
  • Creativity & Innovation
  • Teamwork

Experience

Scientific Researcher - PhD Student (Aug 2024 - Now)

Institute of Biosciences (ICB) - Federral University of Minas Gerais (UFMG)

As a PhD student in Bioinformatics at Federral University of Minas Gerais (UFMG), I focus on deep learning, genomics, and structural biology, specifically in the characterization and design of antimicrobial peptides. My research involves developing computational models for membrane interactions and conducting molecular dynamics simulations to enhance peptide stability and functionality, with a focus on developing future candidates for antimicrobials against antimicrobial resistance.

Scientific Researcher - Master's Student (Jun 2022 - Jul 2024)

Department of Genetics (dGEN) - Federral University of Pernambuco (UFPE)

During my Master's in Genetics and Molecular Biology at the Federal University of Pernambuco (UFPE), I developed a tool called AMP-Identifier, based on machine learning, to identify antimicrobial peptides (AMPs) in genomic sequences. The project involved applying computational techniques to analyze large datasets, enabling the discovery of new molecules and molecular signatures, thus contributing to advancements in bioinformatics and potential therapeutic applications. Additionally, I conducted omics data analyses, enhancing the understanding of peptide functions and their applications in medicine.

Research & Development Analyst (Oct 2020 - Aug 2023)

PickCells

I worked on the development of applications for IoT solutions that use computer vision for pattern recognition in clinically relevant images. My responsibilities included prototyping, developing, and validating systems.

Undergraduate Researcher Fellow (Jan 2020 - May 2022)

Laboratory of Genetics and Vegetal Biotchnology (LGBV) - Federral University of Pernambuco (UFPE)

Conducted research in Bioinformatics aimed at the characterization and optimization of bio-inspired antimicrobial peptides. Additionally, I worked on the investigation of eIF4E sequences in Vigna species, focusing on their potential roles in plant defense mechanisms against pathogens.

Clinical Pathology Intern (Oct 2021 - Mar 2022)

Brazilian Hospital Services Company (EBSERH) - Clinical Hospital of UFPE (HC/PE)

Engaged in activities related to Clinical Pathology within the Clinical Analysis Laboratory at HC/UFPE, specifically in the areas of Sample Screening, Hematology, Biochemistry, Urinalysis, Microbiology, Hormone Testing and Serology. This role involved conducting various diagnostic tests, analyzing results and ensuring quality control within the laboratory, contributing to accurate and timely patient care.

Research, Technological Development and Innovation Intern (Apr 2020 - Aug 2020)

PickCells

Contributed to the development of solutions for the molecular diagnosis of SARS-CoV-2.

Undergraduate Researcher Fellow (Nov 2016 - Dec 2019)

Oswaldo Cruz Foundation (FIOCRUZ)

Engaged in activities in the areas of Structural Biology and Theoretical/Computational Chemistry, focusing on Molecular Modeling and Protein Engineering for diagnostic and vaccine purposes in the Department of Virology and Experimental Therapy.

Undergraduate Researcher Fellow (May 2015 - Dec 2016)

Keizo Asami Institute (iLIKA)

Developed scientific activities in the Molecular Biology sector (in partnership with the Forensic Genetics Institute of the Scientific Police of Pernambuco) in the areas of Human Genetics and Bioinformatics, with an emphasis on Forensic Genetics, Ancestry Markers and Phenotype Prediction.

Education

PhD in Bioinformatics (Ongoing)

Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil

Focusing on machine learning for the identification and design of antimicrobial peptides and the analysis of immune-related biological compounds encoded in multi-omic data. Currently developing scalable in silico methods for the generation of antimicrobial compounds using Transformer-based models.

MBA in Software Engineering (Ongoing)

University of São Paulo (USP), São Paulo, Brazil

Currently studying software engineering principles and practices. The curriculum encompasses full-stack development using Python and JavaScript, microservices architecture, DevOps methodologies, cloud computing with Docker and Kubernetes, information security, and data engineering. The program integrates modern development practices, including agile methodologies, infrastructure as code, and machine learning, equipping professionals to lead complex technological projects and drive organizational innovation.

Postgraduate in Data Science and Analytics (Ongoing)

Pontifical Catholic University of Rio de Janeiro (PUC-Rio), Rio de Janeiro, Brazil

Currently deepening expertise in data-driven decision-making through advanced training in data analysis, statistics and machine learning. This MBA bridges theory and practice, empowering me to extract meaningful insights from complex datasets, build predictive models and apply analytical thinking across real-world problems. Emphasis on Python, data visualization and exploratory analysis, gaining hands-on experience with tools and techniques that support the entire data pipeline—from data wrangling to communication of insights—preparing me to operate at the intersection of analytics, technology and strategy.

MSc in Genetics and Molecular Biology [Emphasis in Bioinformatics] (2024)

Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil

Developed AMP-Identifier, a machine learning-based tool for genome mining focused on the discovery of bioactive molecules. Conducted the first comprehensive characterization of defensins in R. communis, integrating genomic, transcriptomic and structural biology analyses.

BSc in Biomedical Sciences [Emphasis in Clinical Pathology and Bioinformatics] (2022)

Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil

Gained practical experience in hospital laboratories and molecular biology research environments. Further specialized in computational biology through a bioinformatics internship at academic research centers. Undergraduate thesis focused on the eIF4E gene family and the impact of mutations on protein synthesis and susceptibility to viruses that hijack the host translation machinery.

Certifications

[12] Agile Project Management Professional Certificate (Atlassian - 2025)
[11] Career Essentials in Project Management (Microsoft - 2025)
[10] Data-Driven Product Management (National Association of State Boards of Accountancy (NASBA) - 2025)
[9] Microsoft Azure Al Essentials: Workloads and Machine Learning (Microsoft - 2025)
[8] Requirements Engineering and Agile Product Management (Pontifical Catholic University of Rio de Janeiro (PUC-Rio) - 2025)
[7] The Data Science of Healthcare, Medicine, and Public Health (LinkedIn Learning - 2025)
[6] Advanced Gemini for Developers (Deep Mind / Google - 2024)
[5] Career Essentials in GitHub Professional Certificate (GitHub - 2024)
[4] Project Management (Project Management Institute (PMI) - 2024)
[3] Python Programming from Basic to Advanced (Udemy - 2022)
[2] Bioinformatics with Python (Udemy - 2022)
[1] More Achievements (See all certifications on LinkedIn)

Publications

[3] M. V. F. Ferraz et al., Association strength of E6 to E6AP/p53 complex correlates with HPV‐mediated oncogenesis risk, Biopolymers, vol. 113, no. 10, p. e23524, 2022. DOI: 10.1002/bip.23524

[2] L. M. B. Vilela et al., Approaches for Identification and Validation of Antimicrobial Compounds of Plant Origin: A Long Way from the Field to the Market, in Eco-Friendly Biobased Products Used in Microbial Diseases, CRC Press, 2022, pp. 183–222. DOI: 10.1201/9781003243700

[1] R. C. C. da Silva et al., Omics-driven bioinformatics for plant lectins discovery and functionalannotation – A comprehensive review, International Journal of Biological Macromolecules, p. 135511, 2024. DOI: 10.1016/J.IJBIOMAC.2024.135511

Conference Presentations & Invited Talks

[18] Pairing Up for Plant Protection: An In Silico Look at R. communis Defensins Dimerization (Congress)
[17] Structural Assessment of Ricinus communis Defensins and Insights into Their Dimerization Dynamics (Conference)
[16] Mining AMPs and Insights into Their Dynamics (Congress)
[15] AMP-Identifier: A Machine Learning–Based Tool for Identifying Antimicrobial Peptide Sequences in Genomic Data (Congress)
[14] Structural Prediction of the eIF4E and eIF4G in the Leish-eIF4F Complex (Conference)
[13] Molecular Basis of E6/E6AP/p53 in HPV-Mediated Oncogenesis Provides Insights into Inhibitory Strategies (Congress)
[12] Designing Inhibitors for the E6/E6AP/p53 Complex (Conference)
[11] Assessing the Conformational Dynamics and Stability of E6/E6AP/p53 in HPV-Mediated Oncogenesis (Conference)
[10] Structural Analysis of the E6/E6AP/p53 Ternary Complex Associated with HPV-Mediated Oncogenesis (Conference)
[9] Applications of Bioinformatics Tools in Forensic Genetics: Predicting Phenotype and Biogeographic Ancestry in 1000 Genomes Populations (Symposium)
[8] Extraction and Characterization of Human mtDNA Haplogroup from Whole Genome Sequencing Data (Symposium)
[7] Characterization of Mitochondrial DNA and Inference of Maternal Ancestry in Individuals from Pernambuco (Congress)
[6] Genetic Association between IL1B Polymorphism and Lower Susceptibility to Photosensitivity in Systemic Lupus Erythematosus Patients (Congress)
[5] Mitochondrial DNA Analysis and Inference of Maternal Ancestry in Admixed Individualsfrom Pernambuco, Brazil (Congress)
[4] Analysis of Mitochondrial Inheritance and Maternal Ancestry in Admixed Individuals from Pernambuco (Conference)
[3] Prevalence of the Sickle Cell Disease Allele in 1000 Genomes Populations and Its Relationship with Skin Color and Genetic Ancestry (Symposium)
[2] Interactive Seminars in a Biochemistry Course for Undergraduate Biomedicine: Benefits and Problems of Carbohydrates in Modern Life (Congress)
[1] Evaluation of the Efficacy of the MiSeq-FGx Forensic System in 1000 Genomes Populations – 2015 (Symposium)

Teaching Experience

[7] Invited Teacher - Machine Learning Techniques (Federal University of Vale do São Francisco - 2025)
[6] Invited Teacher - Molecular Docking & Dynamics: Breathing Motion into Life’s Building Blocks (Federal University of Vale do São Francisco - 2025)
[5] Invited Teacher - Molecular Modeling with Machine Learning Techniques (Federal University of Vale do São Francisco - 2025)
[4] Invited Teacher - Bioinformatics: A Theoretical-Practical Approach (Federal University of Vale do São Francisco - 2024)
[3] Invited Teacher - Introduction to Bioinformatics: From DNA to Proteins: Databases, Annotation and Protein Modeling Techniques (Catholic University of Pernambuco - 2022)
[2] Teaching Assistant - Human Genetics (Federal University of Pernambuco - 2017-2018)
[1] Teaching Assistant - Molecular Tools Applied to Clinical Diagnosis (Federal University of Pernambuco - 2017-2018)

Awards, Recognitions & Achievements

[10] Travel Grant Award, School on Biological Physics and Biomolecular Simulations in the Machine Learning Era - International Centre for Theoretical Physics South American & South American Institute for Fundamental Research (ICTP-SAIFR)
[9] Honorable Mention – Human and Forensic Genetics (CNPq/UFPE)
[8] Young Geneticist Award of the Northeast (XXI Northeast Genetics Meeting - ENGNE)
[7] Honorable Mention – Postgraduate Genetics Journey (UFPE)
[6] Best Poster Award – XIII Journey of the Genetics and Molecular Biology Program
[5] Travel Grant Award, AI for Protein Design (AI4PD) – The Protein Society
[4] Certificate of Excellence in the Peer Reviewing – Elservier
[3] Highest Admission Score, Ranked first overall among all accepted applicants to the Master’s Program in Genetics and Molecular Biology at the Federal University of Pernambuco (UFPE)
[2] Highest Admission Score, Ranked first overall among all accepted applicants to the PhD Program in Bioinformatics at the Federal University of Minas Gerais (UFMG)
[1] Honorable Mention - Pernambuco Chemistry Olympiad (OPEQ), National Chemistry Olympiad Program & Pernambuco Science Space.

Code/Scripts

A curated vault of open-source code, pipelines and digital experiments I use in my analyses and projects is available for public access. Enter below to explore the repository:

C:\REPOSITORY\code_

Materials

Some lecture notes and other resources from the past (and future) are stored in the digital archives. Click below to enter the directory:

C:\DOCUMENTS\sharing_

101

The biggest problems in the world might be solved by tiny molecules unlocked using AI.




This is the inside story of how David Baker, Demis Hassabis and John Jumper won the 2024 Nobel Prize in Chemistry for advances in computer-assisted protein design and structure prediction. Proteins are biological nano-machines that perform a vast array of vital functions inside of every living.




Satya Nadella on: Why he doesn’t believe in AGI but does believe in 10% economic growth; Microsoft’s new topological qubit breakthrough and gaming world models; Whether Office commoditizes LLMs or the other way around… And much more!




AI models are trained and not directly programmed, so we don’t understand how they do most of the things they do. With two new papers, Anthropic's researchers have taken significant steps towards understanding the circuits that underlie an AI model’s thoughts. In one example from the paper, they find evidence that Claude will plan what it will say many words ahead, and write to get to that destination. They show this in the realm of poetry, where it thinks of possible rhyming words in advance and writes each line to get there. This is powerful evidence that, even though models are trained to output one word at a time, they may think on much longer horizons to do so. Read more: Tracing the thoughts of a large language model




ESM3 is a generative language model for programming biology. In experiments, researchers found ESM3 can simulate 500M years of evolution to generate new fluorescent proteins. Read more: Simulating 500 million years of evolution with a language model




When Thomas Wagner’s son received a diagnosis of Alexander disease, a rare genetic disorder, he set out to learn everything he could. Through these conversations, Thomas has helped jumpstart new research into potential treatmentsd. He realized there might be similarities between Alexander disease, which had very little active research, and other diseases with much more funding and ongoing research. He began to reach out to those researchers, scientists and doctors, many of whom had never heard of Alexander disease before. Through these conversations, Thomas has helped jumpstart new research into potential treatments. Find out more about Thomas' story on Googles' blog: Finding answers, building hope